Equation for depth of treatment

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The DEPTH OF NECROSIS (or apoptosis) is predicted by rearranging the equation from the previous slide to solve for znecrosis.

The znecrosis is linearly proportional to the optical penetration depth, but is proportional to the logarithm of all other factors. Therefore, doubling the optical penetration depth will double the znecrosis. However, one must change any other term 7.4-fold in order to double znecrosis.

The optics of the tissue play a major role in the depth of necrosis (or apoptosis). Here is an example calculation of znecrosis that illustrates typical values for a generic photosensitizer and generic soft tissue.

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